I am implemeting a Flare PDF that matches our company's print standards for look and feel, and the default paragraph font does not come out very well. Compared to a FrameMaker PDF anyway. The only setting that's different is, in FrameMaker I can turn on pair kerning.
In the example below you can see the excess white space after uppercase W, V, and lowercase m, w, h, and a little bit with e.
Flare PDF - no pair kerning
Font Sylfaen, size 10, line spacing 12, letter-spacing -1 px

FrameMaker PDF - with pair kerning
Font Sylfaen, size 10, line spacing 12, Pair Kern turned on
