There are various ways to handle responsive layout in Flare, any advice really depends on how you're approaching it and what you want to achieve.
To start with, I'd read this topic in the help:
http://help.madcapsoftware.com/flare201 ... ontent.htm
This gives you a few options for handling layout of your topic content:
(A) Flare's Responsive Layout control (
Home > Responsive Layout)
(B) Foundation grid (v5.5), which is already included in HTML5 outputs.
You can use any of the Foundation styles for:
Grid layout:
http://foundation.zurb.com/sites/docs/v ... /grid.html
Visibility:
http://foundation.zurb.com/sites/docs/v ... ility.html
In addition to the grid layout systems above, you can also set styles for each medium in your stylesheet (e.g. phone, tablet).