Thank you, Lisa, Kevin and Paul for your expert comments

.
I have indeed noticed differences (mainly in positioning & sizing, as Lisa said), as well as image rendering differences (as far as transparency is concerned).
However, as Paul mentioned, most issues I can probably live with (Am I not picky enough too

??). It just requires being clever about things, for example using IE as a viewer to set up a popup window size (and know that there will probably be a bit too much padding in FF).
The thing that "annoys" me the most is the lack of support of IE6 towards PNG transparency. (I usually use GIFs but for some graphics, I would like a high res rendering and a nice Vista glossy effect, therefore I am using PNGs for these).